Role overview

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

Position Summary (Purpose of Job)

The Principal Portfolio Manager sets strategic direction and enables execution for complex, high-impact portfolios, ensuring alignment with enterprise strategy, business priorities, and regulatory expectations. Operating as a senior individual contributor, this role partners with executive and senior leaders to guide investment planning, governance, and prioritization decisions across a dynamic portfolio.

In an increasingly digital and AI-enabled environment, this role demonstrates learning agility, intellectual curiosity, and balanced risk tolerance, leveraging AI, automation, and digital tools to enhance insight generation, scenario planning, and decision-making. The role serves as a trusted advisor, translating complex portfolio data into actionable insights and driving measurable business outcomes.

Key Responsibilities

Set and refine portfolio direction and investment frameworks aligned to enterprise strategy and technology roadmaps.
Lead governance, prioritization, and decision frameworks that promote transparency, compliance, and execution effectiveness.
Partner with senior leaders to prioritize initiatives, allocate resources, and optimize portfolio investment mix.
Conduct portfolio analysis, scenario planning, and trade-off assessments to inform decisions.
Monitor portfolio health including performance, risks, dependencies, and constraints; mitigate systemic risks.
Lead portfolio reviews and provide data-driven recommendations on investments and resource allocation.
Leverage AI, automation, and digital tools to enhance forecasting, reporting, and real-time insights.
Translate complex data into actionable executive insights to support decision-making.
Drive adoption of best practices and continuous improvement in portfolio management.

Minimum Job Qualifications (Knowledge, Skills, & Abilities)

Advanced expertise in portfolio management, investment prioritization, and governance frameworks.
Exceptional communication and executive presentation skills, with the ability to distill complex portfolio data into clear, actionable insights and influence decision-making at the senior executive level.
Expert level knowledge of project management best practices, and agile development processes
Strong capability in risk analysis, scenario planning, and trade-off decision-making.
Experience aligning investments to strategic objectives and delivering measurable outcomes.
Advanced analytical skills with portfolio visualization and decision-support tools.
Ability to influence without authority in matrixed environments.
Learning agility, curiosity, and adaptability in evolving technology environments.
Comfort with ambiguity and risk in complex, changing conditions.
Understanding of AI, automation, and digital transformation impacts on portfolio strategy.

Business Experience

Bachelor’s degree in Business, IT, Finance, or related field; advanced degree preferred.
12+ years of experience in portfolio management, program leadership, or enterprise strategy.
Experience managing enterprise portfolios with governance, investment planning, and risk management.
Experience supporting large-scale technology or transformation portfolios.
Experience developing executive level communications.

Work Model / Physical Requirements

We are Flex and Connect with 2 days a week in office

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here.

Our Base Pay Range for this position

$142,500 - $237,500

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.

McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: careers.mckesson.com.

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disability_Accommodation@McKesson.com or (Canada) Accessibility@mckesson.ca. Resumes or CVs submitted to this email box will not be accepted.

Join us at McKesson!